Sebuah rangkuman terkait dengan opsi terapi keracunan sianida dan mekanismenya. 1 Hydroxo-cobalamine Digunakan pada kondisi akut. Khususnya pada px dgn Co-existing CO-poisoning. Alternatif lain: 2 Cyanide Antidote kit: - Sodium nitrite 300 mg ampule - Sodium thiosulfate 12.5 g ampule Dosing: Sodium nitrite: DWS: 10 mg/kg given IV for 3 to 5 minutes PED: 0.2 mL/kg, not to exceed 10 mL Sodium thiosulfate: DWS: 12.5 grams in 50 mL, given intravenously for 30 minutes PED: 7 g/m2 and not to exceed 12.5 grams Source: https://www.ncbi.nlm.nih.gov/books/NBK507796/?report=reader#!po=18.0556 https://www.inchem.org/documents/antidote/antidote/ant02.htm#PartNumber:6 https://en.m.wikipedia.org/wiki/Cyanide_poisoning Mekanisme: Sodium thiosulfate: The major route of detoxification of cyanide in the body is conversion to thiocyanate. This reaction requires a source of sulfane sulfur (divalent sulfur bonded to another sulfur) and is catalysed by sulfur transferases (e.g. Rhodanese) Na2S2O3 ...